La Fondation Bill & Melinda Gates annonce un soutien supplémentaire pour promouvoir la R&D locale. Appels à propositions

BRUXELLES25 octobre 2022 /PRNewswire/ — La Fondation Bill & Melinda Gates a annoncé aujourd’hui une série d’initiatives et un appel à propositions en vue de faire progresser l’innovation locale qui soutient les travaux de scientifiques et de chercheurs dans les économies en développement. L’annonce a été faite lors de la réunion annuelle de Grand Challenges plus tôt aujourd’hui.

La réunion de cette année se concentre sur les enseignements tirés de la pandémie de COVID-19, qui a mis en évidence la nécessité de plateformes de R&D à fort impact, de partenariats et de politiques qui comblent efficacement le fossé existant entre l’innovation et l’accès équitable. La réunion rapproche des chercheurs du monde entier pour partager leurs travaux, en apprendre davantage sur les avancées de pointe dans le domaine des soins de santé et permettre une collaboration avec d’autres chercheurs.

« L’équité en santé ne devrait pas uniquement être un énoncé de la raison pour laquelle nous faisons ce travail. Elle devrait guider la façon dont nous le réalisons », a déclaré Kedest Tesfagiorgis, directeur adjoint des Partenariats mondiaux et des grands défis à la Fondation Bill & Melinda Gates. « Lorsque nous soutenons l’innovation locale, nous maximisons l’impact en mettant en lumière différents types de connaissances et de perspectives. »

Dans le cadre de l’Appel mondial à l’action de Grand Challenges, une initiative sur 10 ans annoncée lors de la réunion de l’année dernière pour aider à s’assurer que les scientifiques et les institutions des pays à revenu faible et intermédiaire (PRFI) jouent un rôle central dans l’élaboration du programme mondial de R&D, deux nouvelles initiatives Grand Challenges ont été annoncée par la fondation :

  • La surveillance génomique des agents pathogènes et l’immunologie en Asie Il s’agit d’une invitation à soumission par les chercheurs en Asie du Sud et du Sud-Est pour concevoir et piloter un programme de surveillance génomique ou de développer des capacités en immunologie et séquençage immunitaire du SRAS-CoV-2 afin d’éclairer la réponse épidémique. Un montant allant jusqu’à 300 000 $ par année pour une période maximale de deux ans seront disponibles pour chaque projet, avec un financement supplémentaire potentiel pour les projets qui mettent l’accent sur la recherche d’anticorps monoclonaux.
  • Le renforcement des capacités de modélisation des données pour l’égalité des sexes  Il s’agit d’un appel à propositions lancé aux chercheurs de pays à revenu faible ou intermédiaire pour des projets visant à éliminer les disparités et les lacunes affectant les femmes et les filles dans le domaine de la santé. Cette initiative est axée sur des approches novatrices de modélisation pour faire progresser l’égalité des sexes. Chaque projet recevra jusqu’à 500 000 $ sur une période d’un à trois ans.

« Les sociétés mesurent ce qu’elles valorisent, et pour une grande partie de l’histoire, la société n’a pas valorisé les femmes. Cela signifie que nous essayons de relever des défis mondiaux en matière de santé et de développement sans disposer de toutes les informations nécessaires », a déclaré Anita Zaidi, présidente du département de l’Égalité des sexes à la Fondation Bill & Melinda Gates. « Il est grand temps de placer les femmes et les filles au centre de la modélisation des données qui guide nos solutions. »

En partenariat avec l’Initiative Chan Zuckerberg (CZI), la fondation accordera également des subventions aux chercheurs qui étudient et détectent les agents pathogènes émergents dans les PRFI. Les chercheurs recevront jusqu’à 200 000 $ chacun, pour une période maximale de deux ans, ainsi que le soutien opérationnel et une formation technique du Biohub Chan Zuckerberg  (CZ Biohub). Cet engagement de financement s’appuie sur un partenariat de 2018 entre la fondation, CZI et le CZ Biohub, qui se concentre sur le renforcement des capacités métagénomiques dans les PRFI par le biais d’une Initiative mondiale Grand Challenges.

La réunion annuelle de Grand Challenges 2022 à Bruxelles est organisée par Global Grand Challenges et la Commission européenne, et est coparrainée par Grands Défis Canada, USAID, Wellcome et la Fondation Bill & Melinda Gates.

L’événement de deux jours réunit des dizaines de leaders du paysage mondial de l’innovation en santé, ainsi que des dirigeants de la Fondation Gates, notamment Bill Gates (coprésident et administrateur), Anita Zaidi et Trevor Mundel (Président, Division de la santé mondiale). Les séances plénières seront publiées peu après la réunion sur le site grandchallenges.org/annual-meeting.

À propos de Grand Challenges

La Fondation Bill & Melinda Gates reconnaît que la résolution des défis les plus urgents en matière de santé et de développement mondiaux nécessite que davantage des esprits les plus brillants du monde y travaillent. La série d’initiatives Grand Challenges cherche à mobiliser des innovateurs du monde entier pour aider à résoudre ces défis. Les initiatives Grand Challenges sont unies par leur volonté de favoriser l’innovation, d’orienter la recherche là où elle aura le plus grand impact et d’aider ceux qui en ont le plus besoin. Pour en savoir plus, visitez le site grandchallenges.org.

À propos de la Fondation Bill & Melinda Gates

Guidée par la conviction que chaque vie a la même valeur, la Fondation Bill & Melinda Gates s’efforce d’aider toutes les personnes à mener une vie saine et productive. Dans les pays en développement, elle vise à améliorer la santé des populations et à leur donner la possibilité de ne plus souffrir de la faim et de l’extrême pauvreté. Aux États-Unis, elle vise à faire en sorte que toutes les personnes, en particulier celles qui ont le moins de ressources, aient accès aux opportunités dont elles ont besoin pour réussir à l’école et dans la vie. Basée à Seattle, Washington, la fondation est dirigée par son PDG Mark Suzman, sous la direction des coprésidents Bill Gates et Melinda French Gates et du Conseil d’administration.

Contact pour les médias : media@gatesfoundation.org

IAVI to Accelerate Promising Investigational Sudan Ebolavirus Vaccine Development for Potential Outbreak Research and Response

Merck will provide the investigational vaccine based on a proven platform technology

NEW YORK, NY / ACCESSWIRE / October 25, 2022 / IAVI, a nonprofit scientific research organization, and Merck, known as MSD outside the United States and Canada, have entered into an agreement that could enable IAVI to accelerate the entry of a promising Sudan ebolavirus (SUDV) vaccine candidate that IAVI is developing into clinical evaluation in response to the rapidly spreading outbreak of SUDV disease in Uganda.

Merck plans to produce and provide vials of candidate vaccine from existing investigational drug substance to IAVI to supplement IAVI’s ongoing SUDV vaccine development program. The investigational vaccine being produced is based on the same vesicular stomatitis virus (VSV) viral vector platform that is used in ERVEBO®, Merck’s highly efficacious, single-dose Zaire ebolavirus (EBOV) vaccine that has achieved regulatory approval by the U.S. FDA, the European Medicines Agency (EMA) and a number of regulatory authorities in Africa.

IAVI and Merck have been in discussions with the World Health Organization (WHO), the Coalition for Epidemic Preparedness Innovations (CEPI), and other stakeholders regarding the potential production and supply of doses of investigational SUDV vaccine to help support the WHO’s efforts to conduct a clinical trial of vaccine candidates in Uganda, in partnership with the Government of Uganda.

Mark Feinberg, M.D., Ph.D., president and CEO of IAVI, said, “We are grateful to Merck for supplying the vaccine material, and we look forward to the opportunity to demonstrate vaccine effectiveness and safety so that we are prepared for future outbreaks of SUDV, as well as the SUDV outbreak in Uganda should it not be promptly contained by public health measures alone. Outbreak response is more effective at containing disease spread when countermeasures work quickly, and we are hopeful that this one-dose vaccine, which is likely to generate a rapid immune response, will be a critical part of Sudan virus containment efforts in the future.”

“We are proud to work together with IAVI in support of the World Health Organization’s response to address the Sudan Ebola outbreak in Uganda,” said Beth-Ann Coller, executive director, Global Clinical Development Vaccines, Merck Research Laboratories. “We are moving with urgency to prepare these vials and donate them to IAVI as quickly as possible to help support the efforts of the WHO and the people of Uganda as they grapple with this outbreak.”

Production schedules and quantities are still being defined. Based on the quantities of available bulk drug substance and current plans, Merck hopes to be able to deliver approximately 55,000 doses by the end of the year. IAVI is actively working to accelerate the manufacture of additional doses of IAVI’s VSV-SUDV vaccine should they be needed. The number of doses provided by Merck should be sufficient for conducting Phase I and efficacy studies as well as for public health response if the outbreak in Uganda continues or spreads and should the vaccine be shown to be safe and efficacious.

IAVI will act as developer and regulatory sponsor and will be responsible for all aspects of future development of the vaccine candidate.

No SUDV vaccines have been approved to date, and existing EBOV vaccines and treatments are not effective against SUDV. In the midst of the ongoing SUDV disease outbreak, ensuring that all promising vaccine candidates are evaluated for safety and efficacy could enable vaccine stockpiles to be established for use in future outbreaks.

Vesicular stomatitis virus is the vector that underpins ERVEBO® as well as IAVI’s portfolio of emerging infectious disease vaccine candidates. These include the SUDV vaccine candidate supported by the Biomedical Advanced Research and Development Authority (BARDA) at the U.S. Department of Health and Human Services; a Lassa fever virus vaccine candidate currently in a Phase I trial and supported by the Coalition for Epidemic Preparedness Innovations (CEPI) and the European & Developing Countries Clinical Trials Partnership (EDCTP); a Marburg virus vaccine candidate supported by the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense (DOD) and BARDA; and an intranasal SARS-CoV-2 vaccine candidate supported by the Japan Ministry of Finance. VSV is a harmless animal virus; in the vaccine platform, it is engineered to encode a surface protein from a target pathogen – in this case, SUDV – that stimulates an immune response.

IAVI holds a nonexclusive license to the VSV vaccine candidates from the Public Health Agency of Canada (PHAC). The vector was developed by scientists at PHAC’s National Microbiology Laboratory.

About IAVI

IAVI is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV, tuberculosis, and emerging infectious diseases. Its mission is to translate scientific discoveries into affordable, globally accessible public health solutions. Read more at iavi.org.

Funders who have made the development of IAVI’s VSV-vectored vaccine candidates possible include the Bill & Melinda Gates Foundation; the Government of Canada; the Danish Ministry of Foreign Affairs; the Government of Japan; the Irish Department of Foreign Affairs and Trade; the Netherlands Ministry of Foreign Affairs; the Norwegian Agency for Development Cooperation; the U.K Department for International Development; the U.S. National Institutes of Health (NIH); and through the generous support of the American people from the United States Agency for International Development (USAID).

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IAVI Media Contact

Karie Youngdahl
Head, Global Communications
kyoungdahl@iavi.org
+1 332-282-2890

SOURCE: IAVI

Ethiopia peace talks open in South Africa

The first formal peace talks between the warring sides in the brutal two-year conflict in Ethiopia’s Tigray region opened in South Africa on Tuesday.

Led by the African Union (AU), the talks in Pretoria follow a fierce surge in fighting in recent weeks that has alarmed the international community and triggered fears for civilians caught in the crossfire.

They “have been convened to find a peaceful and sustainable solution to the devastating conflict,” South African President Cyril Ramaphosa’s spokesman Vincent Magwenya told reporters, adding that they would run until October 30.

South Africa hopes “the talks will proceed constructively and result in a successful outcome that leads to peace for all the people of our dear sister country,” he said.

The dialogue between negotiators from the Ethiopian government of Prime Minister Abiy Ahmed and the regional authorities in war-stricken Tigray was launched almost two months to the day since fighting resumed, shattering a five-month truce.

The international community has been calling for an immediate ceasefire, humanitarian access to Tigray and a withdrawal of Eritrean forces, whose return to the conflict has raised fears of renewed atrocities against civilians.

The dialogue is being facilitated by AU Horn of Africa envoy and former Nigerian president Olusegun Obasanjo, along with Kenya’s former leader Uhuru Kenyatta and South Africa’s ex-vice president Phumzile Mlambo-Ngcuka.

AU Commission chair Moussa Faki Mahamat welcomed the launch of the eagerly-awaited process.

He said he was “encouraged by the early demonstration of commitment to peace by the parties and to seek a lasting political solution to the conflict in the supreme interest of Ethiopia”.

Faki said in a statement he “reiterates the AU’s continued commitment to support the parties in an Ethiopian-owned and AU-led process to silence the guns towards a united, stable, peaceful and resilient Ethiopia.”

The Ethiopian government and the rebel Tigray People’s Liberation Front (TPLF) have yet to comment.

– Bloody conflict –

Diplomatic pressure has ratcheted up in recent weeks to end a war which has left millions in need of humanitarian aid and, according to a US estimate, as many as half a million dead.

The talks come as federal forces and their allies in the Eritrean army appear to be gaining the upper hand, seizing a string of towns in Tigray including the strategic city of Shire in offensives that have sent civilians fleeing.

It is impossible to verify developments on the battleground as Tigray — a region of six million people — is largely cut off by a communications blackout and access to northern Ethiopia is severely restricted.

An initial AU effort to bring the two sides to the negotiating table earlier this month failed, with diplomats suggesting logistical issues and a lack of preparedness were to blame.

The Pretoria dialogue represents the first publicly announced talks between the rivals, although a Western official has confirmed that previous secret contacts took place organised by the United States in the Seychelles and twice in Djibouti.

Abiy first sent troops into Tigray in November 2020, promising a quick victory over the northern region’s dissident leaders, the TPLF, after what he said were attacks by the group on federal army camps.

The move followed long-running tensions with the TPLF, which had dominated Ethiopia’s ruling coalition before Abiy came to power in 2018 and sidelined the party.

– Call by Amnesty –

In a rare comment on the conflict last week, Abiy — who won the 2019 Nobel Peace Prize for his rapprochement with Eritrea — said the war “would end and peace will prevail.”

But on Monday, Tigray’s leader Debretsion Gebremichael issued a defiant statement saying: “The Tigray army has the capacity to defeat our enemies totally.”

Amnesty International on Monday urged rival forces to protect civilians in the face of intensifying hostilities.

In a statement, the watchdog charged that air strikes on Tigray’s capital Mekele and the town of Adi Daero in August and September had “killed hundreds of civilians including children.”

It also claimed — without giving sources — that the Eritrean army had in September “extrajudicially executed” at least 40 people, including Eritrean refugees, in the northwestern Tigrayan town of Sheraro.

 

Source: Seychelles News Agency

Djibouti, with IAEA Support, Opens Observatory to Monitor Climate Change Impacts

Djibouti this week inaugurated a research observatory to study the impact of climate change. The observatory, established with the assistance of the International Atomic Energy Agency (IAEA), will help the country prone to drought and famine to better manage water and food resources that are increasingly under threat from global warming. The new facility, the Regional Research Observatory on the Environment and Climate (RROEC), will use nuclear and related techniques to produce data and climate models that can inform political decisions on climate adaptation and resilience for the country, and potentially for the whole East African region.

“Thanks to the IAEA and other partners, this Observatory became a reality – we are able to put in place reliable and operational models for climate change adaptation and lasting resilience,” said the President of the Republic of Djibouti and Head of the Government Ismaïl Omar Guelleh during the opening ceremony on 23 October, which was attended also by President of Somalia Hassan Sheikh Mohamud and other high-level representatives from the region including from Comoros, Ethiopia, Rwanda, Somalia, Sudan and Uganda.

Facing water scarcity due to low levels of precipitation, Djibouti’s population of one million is highly vulnerable to climate change and the country imports nearly all of its food. Higher temperatures, increased aridity, water scarcity and rising sea levels are expected to continue to affect the country.

The Observatory was inaugurated at the Climate Change and Research Conference held from 23 to 25 October, where scientists, students, researchers and decision makers from the East African region discussed regional environmental and climate issues. Over three days, they shared best practices and identified opportunities to initiate collaboration under the newly opened RROEC. The Observatory will in the future build and extend capacity to the whole East African region, where food scarcity caused by changes in climate has become a widespread challenge.

Some of the factors causing this situation are chronic droughts, floods, tropical cyclones and pest invasions. According to available research, if poor seasonal rainfall continues throughout this year, an unprecedented drought in the Horn of Africa, combined with famine, could be imminent. Also, if the temperature rises by 2°C compared with pre-industrial levels, over 90% of East African coral reefs are projected to be severely degraded by bleaching, and African marine and freshwater fisheries will be significantly threatened.

“The burden of climate change falls disproportionately on the most vulnerable among us. Here in Djibouti, and across Africa, higher temperatures, droughts, and rising sea levels threaten lives and livelihoods,” said IAEA Director General Rafael Mariano Grossi during his opening speech. Referring to RROEC, he said: “I am delighted that the IAEA was able to make it happen. But we will not stop here, we will continue to assist Djibouti to achieve its priorities including its climate change adaptation goals.”

The RROEC will use information from isotopes — elements with specific physical and chemical properties — to produce climate models and mapping tools. It will track, among others, the origin of air masses that bring rain, groundwater replenishment rates, and the movement of water through the hydrological cycle. Such information can be used by governments and aid agencies to assist with the management and prevention of water crises or other environmental crises.

For example, isotopes data can be used to produce groundwater vulnerability maps that can inform decision makers about water availability in the aquifers. This information can support management of aquifers, increase awareness about water quality and scarcity, and improve warning systems on droughts and floods in Djibouti and the Horn of Africa.

RROEC has been built with the help of the IAEA’s technical cooperation programme, which supported training programmes, expert activities and the supply of state-of-the-art laboratory equipment. The Observatory is operated by local staff, who have been trained by the IAEA on various nuclear applications related to climate change and adaptation matters.

Environmental protection and climate change is one of the areas identified in the Country Programme Framework signed between Djibouti and the IAEA for the years 2022–2027. This framework is the reference for the medium-term planning of technical cooperation between a Member State and the IAEA, and identifies priority areas where the transfer of nuclear technology through the technical cooperation programme will be directed to support national development priorities.

Between 2012 and 2020, the IAEA supported 120 countries in climate adaptation projects, many of them in Africa. The Agency attends the annual United Nations Climate Change Conferences, more commonly referred to the Conference of the Parties, or COP, and organizes several events to highlight how nuclear technology and applications contribute to tackling climate change. The next COP is starting on 6 November in Egypt.

 

Source: International Atomic Energy Agency

16th Ethio-Djibouti Joint Ministerial Meeting Kicks Off in Addis Ababa

The 16th Ethio-Djibouti Joint Ministerial Meeting kicked off today in Addis Ababa.

The aim of meeting is to discuss on ways of enhancing the cooperation on regional and multilateral and economic integration between the two countries.

During its three-day deliberations, the Joint Ministerial Meeting is expected to discuss on the political, economic, infrastructure, and logistics cooperation between the two countries.

Legal and justice as well as immigration, border trade agreements, and port related issues, agriculture among other areas are also expected to be the other agenda on the meeting, it was indicated.

At the opening of the meeting, Director General of African Affairs at the Ministry of Foreign Affairs, Ambassador Fissaha Shawel said that the two countries have  strong long-standing and historical and bilateral relationship.

He said this meeting will help to exchange views on the importance of the relations between Ethiopia and Djibouti.

Head of the Djiboutian delegation, Mahdi Obsieh said Ethiopia and Djibouti have intertwined with culture, religion, language, tradition and history.

He elaborated that the two brotherly countries have enjoyed close and multifaceted cooperation which this meeting will create opportunity to elevate  the ties to  a high level.

 

Source: Ethiopia News agency